histone-lysine N-methyltransferase SUV420H2; suppressor of variegation 4-20 homolog 2; Suv4-20h2; Su(var)4-20 homolog 2 (SUV420H2)

Function: - histone methyltransferase - specifically trimethylates Lys-20 of histone H4 - histone H4 Lys-20 trimethylation represents a specific tag for epigenetic transcriptional repression - mainly functions in pericentric heterochromatin regions, & plays role in establishment of constitutive heterochromatin in these regions - SUV420H1 is targeted to histone H3 via its interaction with RB1 family proteins (RB1, RBL1 & RBL2) - interacts with HP1 proteins CBX1, CBX3 & CBX5 S-adenosyl-L-methionine + histone L-lysine S-adenosyl-L-homocysteine + histone N(6)-methyl-L-lysine Compartment: - nucleus - associated with pericentric heterochromatin - CBX1 & CBX5 are required for localization to pericentric heterochromatin Alternative splicing: named isoforms=3 Structure: - belongs to the histone-lysine methyltransferase family, Suvar4-20 subfamily - contains 1 SET domain

Properties

SIZE: MW = 52 kD entity length = 462 aa COMPARTMENT: cell nucleus MOTIF: SET domain {103-222} heterochromatin localization {346-435}

Database Correlations

UniProt Q86Y97 Pfam PF00856 ENZYME 2.1.1.43

References

UniProt :accession Q86Y97