histone-lysine N-methyltransferase SUV420H1; suppressor of variegation 4-20 homolog 1; Suv4-20h1; Su(var)4-20 homolog 1 (SUV420H1)

Function: 1) histone methyltransferase 2) specifically trimethylates Lys-20 of histone H4. 3) histone H4 Lys-20 trimethylation represents a specific tag for epigenetic transcriptional repression 4) functions in pericentric heterochromatin regions, thus a role in establishment of constitutive heterochromatin in these regions 5) targeted to histone H3 via its interaction with RB1 family proteins (RB1, RBL1 & RBL2) 6) interacts with HP1 proteins CBX1, CBX3 & CBX5 7) interacts with RB1 family proteins RB1, RBL1 & RBL2 S-adenosyl-L-methionine + histone L-lysine S-adenosyl-L-homocysteine + histone N(6)-methyl-L-lysine Structure: - belongs to the histone-lysine methyltransferase family, Suvar4-20 subfamily - contains 1 SET domain Compartment: - nucleus, associated with pericentric heterochromatin - CBX1 & CBX5 are required for the localization to pericentric heterochromatin Alternative splicing: named isoforms=3 Pathology: - strongly down-regulated in breast cancer cells

Properties

SIZE: MW = 99 kD entity length = 885 aa COMPARTMENT: cell nucleus MOTIF: SET domain {193-312}

Database Correlations

UniProt Q4FZB7 Pfam PF00856 ENZYME 2.1.1.43

References

UniProt :accession Q4FZB7