Search
survival
- time from an initial event until death
- age, sex, & gait speed are factors associated with survival in community-dwelling elderly
Management:
- guideline-recommended cardiovascular drugs (calcium-channel blockers, statins, beta-blockers, ACE inhibitors & ARBs) appear to confer a survival benefit in older adults with multiple comorbidities [2]*
* no survival benefit with SSRIss, SNRIs, clopidogrel, or metformin. The benefits of warfarin varied according to comorbidity.
* mean age, 77 years
* presence of at least 2 of 9 chronic conditions
- atrial fibrillation
- coronary artery disease
- depression
- diabetes
- heart failure
- hyperlipidemia
- hypertension
- thromboembolic disease
- chronic kidney disease
Notes:
- Age, gender, & gait speed are factors associated with survival in community-dwelling elderly [3]
Specific
overall survival; median survival time
progression-free survival (PFS); progression-free interval
References
- Medical Knowledge Self Assessment Program (MKSAP) 17,
American College of Physicians, Philadelphia 2015
- Tinetti ME et al
Association between guideline recommended drugs and death in
older adults with multiple chronic conditions: population based
cohort study.
BMJ 2015;351:h4984
PMID: 26432468
http://www.bmj.com/content/351/bmj.h4984
- Muth, C, Glasziou PP
Guideline recommended treatments in complex patients with
multimorbidity.
BMJ 2015;351:h5145
PMID: 26431846
http://www.bmj.com/content/351/bmj.h5145
- Geriatric Review Syllabus, 11th edition (GRS11)
Harper GM, Lyons WL, Potter JF (eds)
American Geriatrics Society, 2022