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protein sumoylation

Conjugation of a target protein with a SUMO protein (small ubiquitin-related modifier). The SUMO protein modifies an epsilon amino group of lysine in the target protein thus changing conformation of the conjugated protein. Sumoylation is reversible via SUMO-specific ligases & SUMO-specific proteases. Protein sumoylation has been implicated in: [3] 1) cell cycle progression 2) nuclear import 3) regulation of transcription 4) protein turnover (including the amyloid precursor protein) 5) sumoylation competes with ubiquitination

Related

SUMO ligase E3 (sentrin ligase E3) SUMO protein (small ubiquitin-related modifier)

General

protein conjugation

References

  1. Gene Ontology Browser (Mouse) GO:0016925 http://www.informatics.jax.org/searches/GO_form.shtml
  2. http://www.biocarta.com/pathfiles/h_sumoPathway.asp
  3. Hemelaar J, Borodovsky A, Kessler BM, Reverter D et al Specific and covalent targeting of conjugating and deconjugating enzymes of ubiquitin-like proteins. Mol Cell Biol. 2004 Jan;24(1):84-95. PMID: 14673145
  4. Li Y, Wang H, Wang S, Quon D, Liu YW, Cordell B. Positive and negative regulation of APP amyloidogenesis by sumoylation. Proc Natl Acad Sci U S A. 2003 Jan 7;100(1):259-64. Epub 2002 Dec 27. Erratum in: Proc Natl Acad Sci U S A. 2003 Jul 22;100(15):9102. PMID: 12506199