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small ubiquitin-related modifier 4 (SUMO4)
Function:
- ubiquitin-like protein which can be covalently attached to target Lys as a monomer
- does not seem to be involved in protein degradation
- may modulate subcellular localization
- upon oxidative stress, conjugates to various anti-oxidant enzymes, chaperones, & stress defense proteins
- may enhance protein stability & activity
- covalent attachment to its substrates requires prior activation by the E1 complex SAE1-SAE2 & linkage to the E2 enzyme UBE2I
- conjugation of transcription factors may negatively regulate their trasncriptional activity, including:
- NFKBIA, NFKB1, TFAP2A & FOS
- conjugation of transcription factor NR3C1, positively regulates its transcriptional activity
- conjugates NFKBIA
- negatively regulates NFKB1 transcriptional activity
- in contrast to SUMO1, SUMO2 & SUMO3, seems to be insensitive to sentrin-specific proteases due to the presence of Pro-90; this may impair processing to mature form & conjugation to substrates Structure:
- belongs to the ubiquitin family, SUMO subfamily
- contains 1 ubiquitin-like domain
Expression:
- expressed in adult & embryonic kidney, immune tissues, lymph nodes, spleen
Pathology:
- variant Val-55 could be associated with IDDM5 (insulin-dependent diabetes mellitus 5)
Related
insulin-dependent diabetes mellitus 5 (IDDM5)
General
SUMO protein (small ubiquitin-related modifier)
Properties
SIZE: MW = 11 kD
entity length = 95 aa
COMPARTMENT: cell nucleus
MOTIF: UBIQUITIN-LIKE {17-95}
Database Correlations
OMIM correlations
MORBIDMAP 608829
UniProt Q6EEV6
Pfam PF00240
References
- UniProt :accession Q6EEV6
- Wikipedia; Note: SUMO protein entry
http://en.wikipedia.org/wiki/SUMO_protein