Search
small ubiquitin-related modifier 2; SUMO-2; ubiquitin-like protein SMT3B; SMT3 homolog 2; sentrin-2; HSMT3; SUMO-3 (SUMO2, SMT3B, SMT3H2)
Function:
- ubiquitin-like protein which can be covalently attached to target Lys either as a monomer or as a Lys-linked polymer
- does not seem to be involved in protein degradation
- may function as an antagonist of ubiquitin in the degradation process
- plays a role in a number of cellular processes such as
a) nuclear transport
b) DNA replication & repair
c) mitosis
d) signal transduction
- covalent attachment to its substrates requires prior activation by the E1 complex SAE1-SAE2 & linkage to the E2 enzyme UBE2I, & can be promoted by an E3 ligase such as PIAS1-4, RANBP2 or CBX4
- polymeric chains can be formed through Lys-11 cross-linking
- cleavage of precursor form by SENP1 or SENP2 is necessary for function
- crystal packing analysis suggests a possible trimeric assembly; biological significance unknown
- interacts with SAE2 & UBE2I
- covalently attached to a number of proteins
- interacts with PELP1
Structure:
- homotrimer (putative)
- belongs to the ubiquitin family, SUMO subfamily
- contains 1 ubiquitin-like domain
- SUMO2 & SUMO3 are 95% similar at the amino-terminus
Compartment: nucleus. Note: nuclear bodies
Expression: broadly expressed
General
SUMO protein (small ubiquitin-related modifier)
Properties
SIZE: entity length = 95 aa
MW = 11 kD
COMPARTMENT: cell nucleus
MOTIF: Ubiquitin-like {16-95}
Database Correlations
OMIM 603042
UniProt P61956
Entrez Gene 6613
Kegg hsa:6613
References
- UniProt :accession P61956
- Ye ET et al
Ubiquitin-like proteins: new wines in new bottles.
Gene 248:1, 2000
PMID: 10806345
- Li Y, Wang H, Wang S, Quon D, Liu YW, Cordell B.
Positive and negative regulation of APP amyloidogenesis by
sumoylation.
Proc Natl Acad Sci U S A. 2003 Jan 7;100(1):259-64.
Epub 2002 Dec 27.
Erratum in: Proc Natl Acad Sci U S A. 2003 Jul 22;100(15):9102.
PMID: 12506199