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small ubiquitin-related modifier 1; SUMO-1; sentrin; ubiquitin-like protein SMT3C; SMT3 homolog 3; ubiquitin-homology domain protein PIC1; ubiquitin-like protein UBL1; GAP-modifying protein 1; GMP1 (SUMO1, SMT3C, SMT3H3, UBL1, OK/SW-cl43)

Function: - ubiquitin-like protein which can be covalently attached to target Lys as a monomer - does not seem to be involved in protein degradation - may function as an antagonist of ubiquitin in the degradation process - plays a role in a number of cellular processes such as a) nuclear transport b) DNA replication & repair c) mitosis d) signal transduction - involved in targeting RANGAP1 to the nuclear pore complex protein RANBP2 - covalent attachment to its substrates requires prior activation by the E1 complex SAE1-SAE2 & linkage to the E2 enzyme UBE2I, & can be promoted by an E3 ligase such as PIAS1-4, RANBP2 or CBX4 - cleavage of precursor form by SENP1 or SENP2 is necessary for function - interacts with SAE2, UBE2I, RANBP2, PIAS1 & PIAS2 - interacts with PARK2 - covalently attached to a number of proteins such as IKFZ1, PML, RANGAP1, HIPK2, SP100, p53, p73-alpha, MDM2, JUN, DNMT3B & TDG - also interacts with HIF1A, HIPK2, HIPK3, CHD3, EXOSC9, RAD51 & RAD52 Structure: - belongs to the ubiquitin family, SUMO subfamily - contains 1 ubiquitin-like domain Compartment: - nucleus membrane, nucleus speckle - cytoplasm

Related

sentrin-specific protease (SUMO-specific protease)

General

SUMO protein (small ubiquitin-related modifier)

Properties

SIZE: entity length = 101 aa MW = 12 kD COMPARTMENT: cytoplasm cell nucleus MOTIF: Ser phosphorylation site {S2} Ubiquitin-like {20-97} MOTIF: phenylalanine residue {36}

Database Correlations

OMIM 601912 UniProt P63165 Pfam PF00240 Entrez Gene 7341 Kegg hsa:7341

References

  1. UniProt :accession P63165
  2. Wikipedia; Note: SUMO protein entry http://en.wikipedia.org/wiki/SUMO_protein
  3. Li Y, Wang H, Wang S, Quon D, Liu YW, Cordell B. Positive and negative regulation of APP amyloidogenesis by sumoylation. Proc Natl Acad Sci U S A. 2003 Jan 7;100(1):259-64. Epub 2002 Dec 27. Erratum in: Proc Natl Acad Sci U S A. 2003 Jul 22;100(15):9102. PMID: 12506199
  4. Ye ET et al Ubiquitin-like proteins: new wines in new bottles. Gene 248:1, 2000 PMID: 10806345