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sulforaphane
Potent inducer of phase 2 drug metabolizing enzymes with anti-carcinogenic properties.
Occurs naturally in broccoli & brussel sprouts.
Indications: (possible uses)
1) hinders growth of breast cancer cells
2) induces apoptosis of colon cancer cells
3) may diminish risk of macular degeneration
4) may reduce risk of autism
5) potentially of benefit in osteoarthritis of the knee
O=S-(CH2)4-N=C=S
|
CH3
Mechanism of action:
1) potent inducer of phase 2 drug metabolizing enzymes with anti-carcinogenic properties
2) disrupts microtubules
3) reduces hepatic gluconeogenesis [4]
- improves glycemic control in type 2 diabetes
General
isothiocyanate
Database Correlations
PUBCHEM correlations
References
- Merck Index, I2th ed, Merck & Co, Rahway NJ, 1996 # 9315
- Netscape 07/14/04 sites evidence from researchers at Johns
Hopkins University
- Egner PA et al
Rapid and Sustainable Detoxication of Airborne Pollutants
by Broccoli Sprout Beverage: Results of a Randomized
Clinical Trial in China.
Cancer Prevention Research. August 2014 7; 813
PMID: 24913818
http://cancerpreventionresearch.aacrjournals.org/content/7/8/813
- Axelsson AS, Tubbs E, Mecham B
Sulforaphane reduces hepatic glucose production and improves
glucose control in patients with type 2 diabetes.
Sci Transl Med. 2017 Jun 14;9(394).
PMID: 28615356
- Gever J
Really, Soup Might Help in Osteoarthritis?
Not just any soup. And no chicken needed.
MedPage Today. June 24, 2024
https://www.medpagetoday.com/rheumatology/arthritis/110794
- Davidson RK, Watts L, Beasy G et al
The BRoccoli In Osteoarthritis (BRIO study) -
A randomised controlled feasibility trial to examine the potential protective
effect of broccoli bioactives, (specifically sulforaphane), on osteoarthritis.
medRxiv 2024. June 21.
https://www.medrxiv.org/content/10.1101/2024.06.20.24309233v1