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sulfinpyrazone (Anturane)
Tradename: Anturane.
Indications:
- hyperuricemia, gout
Contraindications:
- renal insufficiency
- nephrolithiasis [4]
Dosage: Gout: 100-200 mg PO BID.
Tabs: 100 & 200 mg.
Adverse effects:
1) common (> 10%)
- nausea/vomiting, epigastric pain
2) less common (1-10%)
- dermatitis, rash
3) uncommon (< 1%)
- flushing, dizziness, headache, rash, anemia, leukopenia, increased bleeding time (decreased platelet aggregation), hepatic necrosis, urinary frequency, uric acid stones, nephrotic syndrome
Mechanism of action:
- uricosuric
Interactions
drug interactions
drug adverse effects of NSAIDs
monitor with non steroidal anti-inflammatory agents (NSIADs)
Related
gout
General
non-steroidal anti-inflammatory agent (NSAID)
uricosuric agent
Properties
INHIBITS: cyclooxygenase
MISC-INFO: elimination route KIDNEY
pregnancy-category ?
safety in lactation ?
Database Correlations
PUBCHEM cid=5342
References
- The Pharmacological Basis of Therapeutics, 9th ed.
Gilman et al, eds. Permagon Press/McGraw Hill, 1996
- Kaiser Permanente Northern California Regional Drug
Formulary, 1998
- Deprecated Reference
- Khanna D et al.
2012 American College of Rheumatology guidelines for
management of gout. Part 1: Systematic nonpharmacologic and
pharmacologic therapeutic approaches to hyperuricemia.
Arthritis Care Res (Hoboken) 2012 Oct; 64:1431
PMID: 23024028
- Pui K et al.
Efficacy and tolerability of probenecid as urate-lowering
therapy in gout; clinical experience in high-prevalence
population.
J Rheumatol 2013 Jun; 40:872.
PMID: 23457380