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Sulfacetamide Ophthalmic (Sulamyd, Bleph-10, Sulf-10)
Tradenames: Sulamyd, Bleph-10, Sulf-10
Indications:
- eye infection, eyelid disease
- topical treatment of conjunctivitis due to Escherichia coli, S aureus, S pneumoniae, Streptococcus viridans, H influenzae, Klebsiella, Enterococcus
- corneal ulcers
- adjunctive treatment with systemic sulfonamides for trachoma
Contraindications: sulfa allergy
Dosage:
- 1 drop every 1-6 hours
- ointment BID-QID
- trachoma: 2 drops every 2 hours in combination with appropriate systemic therapy
Drops: 10%, 15%, 30%. ( 5 mL, 15 mL).
Antimicrobial activity:
- Chlamydia [4]
- Gardnerella vaginalis [4]
Adverse effects:
1) not common (1-10%)
- local burning, stinging, irritation
2) uncommon (< 1%)
- headache, Stevens-Johnson syndrome, exfoliative dermatitis, toxic epidermal necrolysis, blurred vision, hypersensitivity reaction, browache
Mechanism of action:
- inhibition of bacterial folic acid synthesis
Interactions
drug adverse effects of sulfonamides
monitor with carbonic anhydrase inhibitors
General
sulfacetamide (Sulfacet)
ophthalmic antibacterial agent
References
- The Pharmacological Basis of Therapeutics, 9th ed.
Gilman et al, eds. Permagon Press/McGraw Hill, 1996
- Drug Information & Medication Formulary, Veterans Affairs,
Central California Health Care System, 1st ed., Ravnan et al
eds, 1998
- Kaiser Permanente Northern California Regional Drug
Formulary, 1998
- Deprecated Reference
- MedlinePlus: Sulfacetamide Ophthalmic
https://medlineplus.gov/druginfo/meds/a601114.html
- DailyMed: SULFACETAMIDE SODIUM - sulfacetamide sodium solution
https://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=92f53dc3-cedc-4963-911a-77c3431d4765&type=display