extracellular sulfatase Sulf-1 (HSulf-1, SULF1, KIAA1077)

Function: - sulfatase, has arylsulfatase activity - highly specific endoglucosamine-6-sulfatase activity - can remove sulfate from C-6 position of glucosamine within specific subregions of intact heparin - diminishes heparan sulfate proteoglycans sulfation - inhibits signaling by heparin-dependent growth factors - diminishes proliferation, & facilitates apoptosis in response to exogenous stimulation - binds 1 Ca⁺² per subunit Kintetic parameters: - Optimum pH is 7.0-8.0 Structure: belongs to the sulfatase family Compartment: endoplasmic reticulum, Golgi, cell surface Expression: - expressed at highest levels in testis, stomach, skeletal muscle, lung, kidney, pancreas, small intestine & colon - detected in normal ovarian surface epithelial cells Pathology: - down-regulation in ovarian cancer - down-regulation cell lines derived froms ovarian carcinoma, breast cancer, pancreatic cancer, renal cell carcinoma, hepatocellular carcinoma

General

Ca+2 binding protein glycoprotein sulfatase

Properties

SIZE: MW = 101 kD entity length = 871 aa COMPARTMENT: golgi endoplasmic reticulum MOTIF: signal sequence {1-22} Ca+2-binding site SITE: 51-51 Ca+2-binding site SITE: 52-52 N-glycosylation site {N64} Ca+2-binding site SITE: 87-87 N-glycosylation site {N111} N-glycosylation site {N131} N-glycosylation site {N148} N-glycosylation site {N170} N-glycosylation site {N197} N-glycosylation site {N240} Ca+2-binding site SITE: 316-316 Ca+2-binding site SITE: 317-317 N-glycosylation site {N623} N-glycosylation site {N773} N-glycosylation site {N783}

Database Correlations

UniProt Q8IWU6 Pfam PF00884

References

UniProt :accession Q8IWU6