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succinyl coenzyme A
Function:
- succinyl CoA is an intermediate in the citric acid cycle.
- it is formed from alpha-ketoglutarate via alpha-ketoglutarate dehydrogenase in a reaction that feeds electrons into the electron transport chain via NADH
- enzyme: alpha-ketoglutarate dehydrogenase
- substrates: alpha-ketoglutarate + NAD+ + coenzyme-A
- products: succinyl-CoA + CO2 + NADH
- it is hydrolyzed to form succinate by succinyl CoA synthase
- enzyme: succinyl-CoA synthetase
- substrates: succinyl-CoA + GDP + H2PO4-
- products: succinate + coenzyme-A + GTP
- succinyl CoA also serves as a port of entry into the citric acid cycle, from methylmalonyl CoA in a vitamin B12-dependent reaction catalyzed by methylmalonyl CoA mutase.
* see citric acid cycle for role of succinyl CoA in citric acid cycle
- succinyl CoA serves as an intermediate in the catabolism of odd chain fatty acids, cholesterol & the amino acids methionine, valine & isoleucine
- succinyl CoA & glycine condense to form delta-aminolevulinate in the first step of the biosynthesis of heme in a reaction catalyzed by delta-aminolevulinate synthase within mitochondria.
Interactions
molecular events
Related
citric acid cycle, Krebs cycle or tricarboxylic acid [TCA] cycle
heme synthesis
General
acyl Coenzyme A
intermediary metabolite
succinate; succinic acid
Properties
COMPARTMENT: mitochondrial matrix
Database Correlations
PUBCHEM correlations
References
- Biochemistry, L. Stryer, WH Freeman & Co, New York, 1988,
pg 376, 506, 594
- Wikipedia: Succinyl-CoA
https://en.wikipedia.org/wiki/Succinyl-CoA