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subventricular zone (SVZ)
Structure:
- paired brain structure within the lateral walls of the lateral ventricles
- consists of 4 distinct layers of variable thickness, cell density & cellular composition
- layer 1:
- monolayer of ependymal cells lining lateral ventricle
- layer 2:
- hypocellular layer containing a network of GFAP-positive astrocytic processes linked to junctional complexes
- layer 3:
- ribbon of astrocyte cell bodies
- layer 4:
- transition zone between Layer 3 & the brain parenchyma; contains an abundance of myelin
* layer 2 as such not comparable in mouse & human [1]
Clinical significance:
- along with the dentate gyrus & the olfactory bulb, the SVZ is one of 3 regions of neurogenesis in the adult mammalian brain*
- proliferating neural stem cells in mice may migrate to the olfactory bulb
- far fewer neuroblasts in humans, origin & fate unknown [4]
* In mice, subventricular astrocytes are neural stem cells
Notes:
- also see neuroblast
General
brain structure
References
- Wikipedia: Subventricular zone
https://en.wikipedia.org/wiki/Subventricular_zone
- Doetsch F et al
Subventricular Zone Astrocytes Are Neural Stem Cells in the
Adult Mammalian Brain
Cell Volume 97, Issue 6, 11 June 1999, Pages 703-716
http://www.sciencedirect.com/science/article/pii/S0092867400807837
- Alvarez-Buylla A, Garcia-Verdugo JM
Neurogenesis in Adult Subventricular Zone
Journal of Neuroscience, 1 February 2002, 22(3): 629-634
http://www.jneurosci.org/content/22/3/629.short
- Sanai N, Berger MS, Garcia-Verdugo JM, Alvarez-Buylla A.
Comment on "Human neuroblasts migrate to the olfactory bulb
via a lateral ventricular extension".
Science. 2007 Oct 19;318(5849):393; author reply 393.
PMID: 17947566 Free Article