SU.VLMAX study

Design: - 13,017 adults; - 5141 men, mean age 51 - 7876 women, mean age 47 - 7.5 years of follow-up Treatment: - antioxidant combination of: ascorbate 120 mg vitamin E 30IU beta-carotene 6 mg selenium 100 ug Zn⁺² 20 mg - placebo Results: - overall, no reduction in risk of cancer, cardiovascular disease, or mortality - in men, significant reductions in cancer (RR 0.69) & mortality (RR 0.63) - in men in placebo group, cancer risk negatively correlated with baseline beta-carotene levels (RR for highest quintile relative to lowest quintile = 0.55)

References

Journal Watch 25(1):2, 2005 Hercberg S, Galan P, Preziosi P, Bertrais S, Mennen L, Malvy D, Roussel AM, Favier A, Briancon S. The SU.VI.MAX Study: a randomized, placebo-controlled trial of the health effects of antioxidant vitamins and minerals. Arch Intern Med. 2004 Nov 22;164(21):2335-42. PMID: 15557412