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syntaxin-8 (STX8)
Function:
- vesicle trafficking protein
- functions in early secretory pathway, possibly by mediating retrograde transport from cis-Golgi membranes to the endoplasmic reticulum (ER)
- forms a SNARE complex with STX7, VTI1B & VAMP8 which functions in the homotypic fusion of late endosomes
- part of SNARE core complex containing STX7, VAMP8 & VTI1B
- interacts with VAMP8 (putative)
Structure:
- belongs to the syntaxin family
- contains 1 t-SNARE coiled-coil homology domain
Compartment:
- membrane
- preferentially associated with early endosome
- to lesser extent, also present in late endosome, plasma membrane & coated pits (putative)
Expression:
- expressed in heart > brain, kidney, liver, lung, placenta, skeletal muscle, spleen & pancreas
General
syntaxin
Properties
SIZE: entity length = 236 aa
MW = 27 kD
COMPARTMENT: intracellular vesicle
MOTIF: coiled coil {42-65}
SNARE motif {145-207}
transmembrane domain {216-232}
Vesicular {233-236}
Database Correlations
OMIM 604203
UniProt Q9UNK0
Pfam PF05739
Entrez Gene 9482
Kegg hsa:9482
References
UniProt :accession Q9UNK0