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syntaxin-7 (STX7)
Function:
- may be involved in protein trafficking from the plasma membrane to the early endosome as well as in homotypic fusion of endocytic organelles
- mediates the endocytic trafficking from early endosomes to late endosomes & lysosomes
- forms a SNARE complex with VTI1B, STX8 & VAMP8 which functions in the homotypic fusion of late endosomes
- interacts with VPS33A
- found in a complex with VAMP8 & VTI1B in the liver
- part of the SNARE core complex containing VAMP8, STX8 & VTI1B (putative)
- interacts with VPS11, VPS16 & VPS18
Structure:
- belongs to the syntaxin family
- contains 1 t-SNARE coiled-coil homology domain
Compartment:
- early endosome membrane
Alternative splicing: named isoforms=2
Expression:
- expressed in placenta > heart, skeletal muscle, kidney & brain > pancreas, lung & liver
General
phosphoprotein
syntaxin
Properties
SIZE: entity length = 261 aa
MW = 30 kD
COMPARTMENT: intracellular vesicle
MOTIF: acetylation site
SITE: N-TERMINUS
EFFECTOR-BOUND: acetyl
coiled coil {47-69}
Thr phosphorylation site {T79}
Ser phosphorylation site {S125}
Ser phosphorylation site {S126}
Ser phosphorylation site {S129}
SNARE motif {165-227}
transmembrane domain {239-259}
vesicular {260-261}
Database Correlations
OMIM 603217
UniProt O15400
PFAM correlations
Entrez Gene 8417
Kegg hsa:8417
References
UniProt :accession O15400