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syntaxin-5 (STX5, STX5A)
Function:
- mediates endoplasmic reticulum to Golgi transport
- part of a ternary complex containing STX5A, NSFL1C & VCP
- identified in a unique SNARE complex composed of the Golgi SNAREs GOSR1, GOSR2 & YKT6 (putative)
Structure:
- belongs to the syntaxin family
- contains 1 t-SNARE coiled-coil homology domain
Compartment:
- endoplasmic reticulum-Golgi intermediate compartment membrane
- Golgi apparatus membrane
Alternative splicing:
- alternative initiation
- named isoforms=3
Note:
- produced by alternative initiation at Met-55 of isoform 1
- produced by alternative initiation & alternative splicing
General
syntaxin
Properties
SIZE: entity length = 355 aa
MW = 40 kD
COMPARTMENT: golgi
endoplasmic reticulum
MOTIF: SNARE motif {263-325}
MOTIF: coiled coil {287-318}
transmembrane domain {334-354}
Vesicular {355-355}
Database Correlations
OMIM 603189
UniProt Q13190
PFAM correlations
Entrez Gene 6811
Kegg hsa:6811
References
UniProt :accession Q13190