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syntaxin-4; renal carcinoma antigen NY-REN-31 (STX4, STX4A)
Function:
- plasma membrane t-SNARE that mediates docking of transport vesicles
- necessary for translocation of SLC2A4 from intracellular vesicles to plasma membrane (putative)
- role in docking of synaptic vesicles at presynaptic active zones (putative)
- binds STXBP3 & STXBP6
- binding to STXBP3 excludes binding with SNAP25
- interacts with SNAP23 & SNAP25BP
- found in a complex with VAMP8 & SNAP23 in pancreas (putative)
- interacts with VAMP2 & STXBP4 (putative)
- detected in a complex with SNAP23 & STXBP4
- interaction with STXBP4 excludes interaction with VAMP2 (putative)
- interacts with STX4A
Structure:
- belongs to the syntaxin family
- contains 1 t-SNARE coiled-coil homology domain
Compartment: membrane
General
syntaxin
Properties
SIZE: entity length = 297 aa
MW = 34 kD
COMPARTMENT: intracellular vesicle
MOTIF: Ser phosphorylation site {S14}
Ser phosphorylation site {S15}
coiled coil {43-163}
MOTIF: Tyr phosphorylation site {Y115}
Ser phosphorylation site {S117}
SNARE motif {200-262}
MOTIF: Tyr phosphorylation site {Y251}
transmembrane domain {276-296}
Database Correlations
OMIM 186591
UniProt Q12846
PFAM correlations
Entrez Gene 6810
Kegg hsa:6810
References
UniProt :accession Q12846