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syntaxin-1A; syntaxin-A; neuron-specific antigen HPC-1 (STX1A, STX1)
Function:
- role in docking of synaptic vesicles at presynaptic active zones
- may play a critical role in neurotransmitter exocytosis
- part of the SNARE core complex containing SNAP25, VAMP2 & STX1A
- binds SYTL4 & STXBP6
- found in a ternary complex with STX1A & SNAP25 (putative)
- found in a complex with VAMP8 & SNAP23
- interacts with VAPA & SYBU
- may associate with N-type Ca+2 channel & synaptotagmin
Structure:
- belongs to the syntaxin family
- contains 1 t-SNARE coiled-coil homology domain
Compartment:
- cell membrane
- isoform 2: secreted (probable)
Alternative splicing: named isoforms=3
Expression:
- isoform 1 is highly expressed in embryonic spinal cord & ganglia & in adult cerebellum & cerebral cortex
- isoform 2 is expressed in heart, liver, fat, skeletal muscle, kidney & brain
Pathology:
- haploinsufficiency of STX1A may be the cause of certain cardiovascular & musculo-skeletal abnormalities observed in Williams-Beuren syndrome
Interactions
molecular events
Related
N-type Ca+2 channel or neuronal-type Ca+2 channel
synaptotagmin
General
syntaxin
Properties
SIZE: entity length = 288 aa
MW = 33 kD
COMPARTMENT: intracellular vesicle
MOTIF: Ser phosphorylation site {S14}
coiled coil {68-109}
SNARE motif {192-254}
transmembrane domain {266-286}
Database Correlations
OMIM 186590
UniProt Q16623
PFAM correlations
Entrez Gene 6804
Kegg hsa:6804
References
- Sollner T, Whiteheart SW, Brunner M et al
SNAP receptors implicated in vesicle targeting and fusion.
Nature. 1993 Mar 25;362(6418):318-24.
PMID: 8455717
- Inoue A, Akagawa K.
Neuron-specific antigen HPC-1 from bovine brain reveals
strong homology to epimorphin, an essential factor involved
in epithelial morphogenesis: identification of a novel protein
family.
Biochem Biophys Res Commun. 1992 Sep 16;187(2):1144-50.
PMID: 1530610
- Yoshida A, Oho C, Omori A, Kuwahara R, Ito T, Takahashi M.
HPC-1 is associated with synaptotagmin and omega-conotoxin receptor.
J Biol Chem. 1992 Dec 15;267(35):24925-8.
PMID: 1334074
- UniProt :accession Q16623
Component-of
ABI1/STX1A/SNAP25 complex