matrix metalloproteinase-11 (matrixin-11, stromelysin-3, transin-3, MMP11, STMY3)

Function: - role in the progression of epithelial malignancies (putative) - precursor is cleaved by a furin endopeptidase Cofactor: - binds 1 Ca⁺² per subunit (putative) - binds 2 Zn⁺² per subunit (putative) Structure: - conserved Cys present in the cysteine-switch motif binds the catalytic Zn⁺², thus inhibiting the enzyme; dissociation of the Cys from the Zn⁺² upon the activation-peptide release activates the enzyme - belongs to the peptidase M10A family - contains 4 hemopexin-like domains Expression: - specifically expressed in stromal cells of breast carcinomas

Properties

SIZE: entity length = 488 aa MW = 55 kD COMPARTMENT: extracellular matrix MOTIF: signal sequence {1-31} Cysteine switch {78-85} MOTIF: Zn+2-binding site SITE: 80-80 Zn+2-binding site SITE: 166-166 Ca+2-binding site SITE: 171-171 Ca+2-binding site SITE: 172-172 Ca+2-binding site SITE: 174-174 Ca+2-binding site SITE: 176-176 Zn+2-binding site SITE: 179-179 Zn+2-binding site SITE: 192-192 Zn+2-binding site SITE: 215-215 glutamate residue {E216} Zn+2-binding site SITE: 219-219 Zn+2-binding site SITE: 225-225 cysteine residue {C294} MODIFICATION: cysteine residue {C480} Hemopexin-like 1 {298-341} Hemopexin-like 2 {343-384} Hemopexin-like 3 {387-434} Hemopexin-like 4 {436-480} MOTIF: cysteine residue {C480} MODIFICATION: cysteine residue {C294} SECRETED-BY: fibroblast

Database Correlations

OMIM 185261 UniProt P24347 PFAM correlations Entrez Gene 4320 Kegg hsa:4320