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c-jun NH2 terminal kinase, jun kinase (JNK) or stress-activated protein kinase (SAPK)

Function: - subgroup of the MAP kinases, regulated by both Ser/Thr & Tyr phosphorylation - JNKs bind to the c-Jun transactivation domain & phosphorylate Ser-63, Ser-73 & some secondary sites - activity is stimulated by UV irradiation - SAPKs are poorly activated by mitogens, but are the major c-jun NH2 terminal kinase(s) activated in response to cellular stress & TNF-alpha - SAPKs are also activated in response to sphingomyelinase which elicits a subset of cellular responses to TNF-alpha

Interactions

molecular events

Related

adapter protein CIKS; connection to IKK & SAPK/JNK; TRAF3-interacting protein 2; nuclear factor NF-kappa-B activator 1; ACT1 (TRAF3IP2, C6orf2, C6orf4, C6orf5, C6orf6)

Specific

c-jun NH2 terminal kinase 1 (JNK1, JNK46, mitogen-activated protein kinase 8) c-jun NH2 terminal kinase 2 (JNK2, JNK55, mitogen-activated protein kinase 9) c-Jun NH2 terminal kinase 3 (mitogen-activated protein kinase 10, stress-activated protein kinase JNK3, p49 3F12 MAP kinase)

General

mitogen-activated protein kinase (MAP kinase) or microtubule-associated protein kinase

Figures/Diagrams

Figures/diagrams/slides/tables related to c-jun NH2 terminal kinase, jun kinase (JNK) or stress-activated protein kinase (SAPK)

Properties

SIZE: MW = 42-44 kD COMPARTMENT: cytoplasm STATE: active state MOTIF: Thr-phosphate Tyr-phosphate kinase domain MOTIF: ATP-binding site NAME: ATP-binding site

References

  1. Hibi M et al. Identification of an oncoprotein- and UV-responsive protein kinase that binds and potentiates the c-Jun activation domain. Genes Dev 1993, 7:2135-48 PMID: 8224842
  2. Sun H, Tonks NK, Bar-Sagi D. Inhibition of Ras-induced DNA synthesis by expression of the phosphatase MKP-1. Science. 1994 Oct 14;266(5183):285-8. PMID: 7939666
  3. Kyriakis JM, Banerjee P, Nikolakaki E, Dai T, Rubie EA, Ahmad MF, Avruch J, Woodgett JR. The stress-activated protein kinase subfamily of c-Jun kinases. Nature. 1994 May 12;369(6476):156-60. PMID: 8177321