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streptozocin (Zanosar)
Tradename: Zanosar.
Indications:
1) treatment of metastatic islet cell carcinoma of the pancreas
2) carcinoid tumor & carcinoid syndrome
3) Hodgkin's disease
4) palliative treatment of colorectal carcinoma
Contraindications: Caution:
1) avoid aspirin
2) use electric razor
Dosage:
1) may be injected by rapid IV push
2) dosage adjustment for renal failure
3) refrigerate & protect from light
4) discard refrigerated reconstituted solutions after 12 hours
Powder for injection: 1 g
Adverse effects:
1) common (> 10%)
- nephrotoxicity (25-75%), nausea/vomiting
2) less common (1-10%)
- diarrhea, hypoglycemia, pain at site of injection
3) uncommon (< 1%)
- liver dysfunction, leukopenia, thrombocytopenia, hematologic toxicity
4) other
- may cause permanent sterility
- may cause birth defects
Drug interactions:
1) phenytoin
2) other potentially nephrotoxic drugs
Test interactions: increases serum K+
Interactions
drug interactions
General
antibiotic antineoplastic agent
Properties
MISC-INFO: pregnancy-category X
safety in lactation -
Database Correlations
PUBCHEM correlations
References
- Kaiser Permanente Northern California Regional Drug
Formulary, 1998
- Department of Veterans Affairs, VA National Formulary