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streptococcal pyrogenic exotoxin A
Streptococcal M protein types 1 & 3 produce streptococcal pyrogenic exotoxin A, B &/or C.
Epidemiology:
- a new emm1 strain (M1UK) of Streptococcus pyogenes associated with an outbreak of scarlet fever in 2014-2016 in the UK produces 9X more streptococcal pyrogenic exotoxin A than other emm1 strains [2]
Related
group A beta-hemolytic streptococcus
streptococcal pyrogenic exotoxin B
streptococcal pyrogenic exotoxin C
General
streptococcal pyrogenic exotoxin
References
- Medical Knowledge Self Assessment Program (MKSAP) 11, American
College of Physicians, Philadelphia 1998
- Lynskey NN, Jauneikaite E, Li HK et al
Emergence of dominant toxigenic M1T1 Streptococcus pyogenes clone
during increased scarlet fever activity in England: a population-
based molecular epidemiological study.
Lancet Infectious Diseases. Sept 10, 2019
PMID: 31519541 Free Article
https://www.thelancet.com/journals/laninf/article/PIIS1473-3099(19)30446-3/fulltext
- Brouwer S, Lacey JA, You Y, Davies MR, Walker MJ.
Scarlet fever changes its spots.
Lancet Infectious Diseases. Sept 10, 2019
PMID: 31519542 Free Article
https://www.thelancet.com/journals/laninf/article/PIIS1473-3099(19)30494-3/fulltext