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serine-threonine kinase receptor-associated protein; MAP activator with WD repeats; UNR-interacting protein; WD-40 repeat protein PT-WD (STRAP, MAWD, UNRIP)
Function:
- conponent of the core SMN complex
- the SMN complex plays an essential role in spliceosomal snRNP assembly in the cytoplasm & is required for pre-mRNA splicing in the nucleus
- STRAP may play a role in the cellular distribution of the SMN complex
- associates with the SMN complex in the cytoplasm but not in the nucleus
- also interacts with CSDE1/UNR & MAWBP
- associates with TGF-beta receptor 1 & TGF-beta receptor 2
- shows smad7 synergistic inhibition of TGF-beta signaling
Structure:
- belongs to the WD repeat STRAP family
- contains 7 WD repeats
Compartment:
- cytoplasm, nucleus
- localized predominantly in the cytoplasm but also found in the nucleus
Interactions
molecular events
General
phosphoprotein
WD repeat protein family
Properties
SIZE: entity length = 350 aa
MW = 38 kD
COMPARTMENT: cytoplasm
cell nucleus
MOTIF: WD repeat {12-56}
WD repeat {57-96}
WD repeat {98-137}
WD repeat {141-179}
WD repeat {180-212}
WD repeat {221-262}
WD repeat {263-302}
Ser phosphorylation site {S335}
Ser phosphorylation site {S338}
Database Correlations
OMIM 605986
UniProt Q9Y3F4
Pfam PF00400
Entrez Gene 11171
Kegg hsa:11171
References
- UniProt :accession Q9Y3F4
- Datta PK et al
Identification of STRAP, a novel WD domain protein in
transforming growth factor-beta signaling.
J Biol Chem 273(52):34671-4, 1998
PMID: 9856985