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STE20-related adapter protein (STRAD alpha, NY-BR-96 antigen, STRAD, LYK5)
Function:
1) pseudokinase, protein kinase domain is catalytically inactive (by prediction)
2) in complex with CAB39, binds to & activates STK11
3) relocates STK11 from nucleus to cytoplasm
4) role in STK11-mediated G1 cell cycle arrest
Structure:
- contains 1 protein kinase domain (catalytically inactive)
Compartment: nucleus, cytoplasm
Alternative splicing: named isoforms=3
General
phosphoprotein
Properties
SIZE: MW = 48 kD
entity length = 431 aa
COMPARTMENT: cytoplasm
cell nucleus
MOTIF: kinase domain
SITE: 69-379
MOTIF: ATP-binding site
NAME: ATP-binding site
Thr phosphorylation site {T329}
Thr phosphorylation site {T419}
Database Correlations
OMIM 608626
UniProt Q7RTN6
Pfam PF00069
References
UniProt :accession Q7RTN6