serine/threonine protein kinase 38-like; NDR2 protein kinase; nuclear Dbf2-related kinase 2 (STK38L, KIAA0965 NDR2)

Function: - role in regulation of structural processes in both differentiating & mature neurons (putative) - activated by binding of S100B which releases autoinhibitory N-lobe interactions, enabling ATP binding & autophosphorylation of Ser-282 - Thr-442 then undergoes Ca⁺²-dependent phosphorylation by STK24/MST3 - interactions between phosphorylated Thr-442 & the N-lobe promote additional structural changes that complete activation - autoinhibition is also released by binding of MOB1/MOBKL1A & MOB2/HCCA2 to the N-terminal of STK38L - phosphorylated upon DNA damage, probably by ATM or ATR - homodimeric S100B binds two molecules of STK38L - interacts with MOB1 & MOB2 Cofactor: Mg⁺² Structure: - belongs to the protein kinase superfamily, AGC Ser/Thr protein kinase family - contains 1 AGC-kinase C-terminal domain - contains 1 protein kinase domain Compartment: - cytoplasm, cytoskeleton, membrane - associated with the actin cytoskeleton - colocalizes with STK24/MST3 in the membrane Expression: - ubiquitously expressed - highest expression in thymus

Properties

SIZE: entity length = 464 aa MW = 54 kD COMPARTMENT: cytoplasm STATE: active state MOTIF: acetylation site SITE: N-TERMINUS EFFECTOR-BOUND: acetyl S100B binding {63-88} MOTIF: Thr phosphorylation site {T75} kinase domain SITE: 90-383 MOTIF: ATP-binding site NAME: ATP-binding site SITE: 96-104 ATP-binding site NAME: ATP-binding site SITE: 119-119 aspartate residue {D213} Ser phosphorylation site {S282} AGC-kinase C-terminal {384-453} MOTIF: Thr phosphorylation site {T442} Thr phosphorylation site {T450}

Database Correlations

UniProt Q9Y2H1 PFAM correlations Entrez Gene 23012 Kegg hsa:23012 ENZYME 2.7.11.1

References

UniProt :accession Q9Y2H1