serine/threonine protein kinase 17A; DAP kinase-related apoptosis-inducing protein kinase 1 (STK17A, DRAK1)

Function: - acts as a positive regulator of apoptosis Structure: - belongs to the protein kinase superfamily, CAMK Ser/Thr protein kinase family, DAP kinase subfamily - contains 1 protein kinase domain Compartment: nucleus Expression: - highly expressed in placenta - lower expression in heart, lung, skeletal muscle, kidney & pancreas

General

nuclear protein serine/threonine kinase

Properties

SIZE: entity length = 414 aa MW = 47 kD COMPARTMENT: cell nucleus MOTIF: Ser phosphorylation site {S9} Ser phosphorylation site {S28} proline-rich region SITE: 33-37 MOTIF: proline residue (SEVERAL) kinase domain SITE: 61-321 MOTIF: ATP-binding site NAME: ATP-binding site SITE: 67-75 ATP-binding site NAME: ATP-binding site SITE: 90-90 aspartate residue {D186} STATE: active state

Database Correlations

OMIM 604726 UniProt Q9UEE5 Pfam PF00069 Entrez Gene 9263 Kegg hsa:9263 ENZYME 2.7.11.1

References

UniProt :accession Q9UEE5