Serine/threonine kinase 11-interacting protein (LKB1-interacting protein 1, STK11IP, KIAA1898, LIP1, LKB1IP, STK11IP1)

Function: - may regulate STK11 function by controlling its subcellular localization - found in a ternary complex composed of STK11, STK11IP & SMAD4 - interacts with STK11 & SMAD4 - phosphorylated Structure: - belongs to the STK11IP family - contains 6 LRR repeats (leucine-rich repeats) Compartment: - cytoplasm - some cells show granular or punctate expression - colocalizes with STK11 & SMAD4 in granular or punctate structures Alternative splicing: named isoforms=2 Note: uncertain whether Met-1 or Met-12 is the initiator

Properties

GENERAL: uncharacterized protein SIZE: entity length = 1099 aa MW = 121 kD COMPARTMENT: cytoplasm FORM: Serine/threonine kinase 11-interacting protein MOTIF: leucine-rich repeat SITE: 173-196 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 197-219 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 220-242 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 244-264 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 265-290 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 292-312 MOTIF: leucine residue (SEVERAL) glutamate-rich region {485-604} MOTIF: glutamate residue (SEVERAL)

Database Correlations

OMIM 607172 UniProt Q8N1F8 Pfam PF00560

References

UniProt :accession Q8N1F8