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steroid psychosis

Clinical manifestations: 1) bipolar symptoms 2) steroid psychosis severe in 6%, mild-moderate in 28% [1] 3) begins 7-10 days after starting 4) dosage is directly related to the incidence of adverse effects [1] - 26% incidence with 120 mg/day of methylprednisolone for 8 days [1] - 1.3% incidence with < 40 mg prednisone/day - 4.6% incidence with 41-80 mg prednisone/day - 18% incidence with > 80 mg prednisone/day 5) case report of steroid psychosis 1 week after 7 days of IV dexamethasone 6 mg/day [2]

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psychosis

References

  1. Warrington TP, Bostwick JM. Psychiatric adverse effects of corticosteroids. Mayo Clin Proc. 2006 Oct;81(10):1361-7. PMID: 17036562 Review
  2. Kazi SE, Hoque S. Acute Psychosis Following Corticosteroid Administration Cureus. 2021 Sep 19;13(9):e18093 PMID: 34692307 Free PMC article