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cytochrome P450 11B1 (CYP11B1, steroid-11-hydroxylase B1, steroid 11 beta-monooxygenase)
Function:
1) steroid 11-beta-hydroxylase activity
2) 18 or 19-hydroxylation of steroids
3) aromatization of androstendione to estrone
Compartment: mitochondrial membrane
Pathology:
- defects in CYP11B1 are the cause of congenital adrenal hyperplasia type 4
Laboratory:
- CYP11B1 gene mutation
Related
CYP11B1 gene mutation
steroid-11-hydroxylase-B1 gene or CYP11B1
General
cytochrome P450 11B (steroid-11-beta hydroxylase)
Properties
SIZE: MW = 58 kD
entity length = 503 aa
COMPARTMENT: mitochondria
MOTIF: Iron [Fe]-binding site
SITE: 450-450
Database Correlations
OMIM correlations
UniProt P15538
Pfam PF00067
Entrez Gene 1584
ENZYME 1.14.15.4
References
OMIM :accession 202010