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Strategy of Blood Pressure Intervention in the Elderly Hypertensive Patients (STEP) trial

Study characteristics: - 8,500 patients ages 60-80 in China [1] Treatment - target systolic blood pressure 110-130 mm Hg Results: - 26% reduction in risk of stroke, acute myocardial infarction, hospitalization for unstable angina, acute decompensated heart failure, coronary revascularization, atrial fibrillation, or cardiovascular death - benefit independent of baseline diastolic blood pressure [2] - no mention of all-cause mortality, quality of life, cognition or falls

Related

Sprint study

General

hypertension clinical trials

References

  1. Phend C Lower BP Targets Again Affirmed in Major Trial. STEP trial from China shows major benefits in older population. MedPage Today August 30, 2021 https://www.medpagetoday.com/meetingcoverage/esc/94277 - Zhang W, Zhang S, Deng Y et al Trial of Intensive Blood-Pressure Control in Older Patients with Hypertension. N Engl J Med. August 30, 2021 PMID: 34491661 https://www.nejm.org/doi/full/10.1056/NEJMoa2111437
  2. Yang R, Huang R, Zhang L et al. Influence of baseline diastolic blood pressure on the effects of intensive blood pressure lowering: Results from the STEP randomized trial. Hypertension 2023 Oct 10; [e-pub] PMID: 37814892 https://www.ahajournals.org/doi/10.1161/HYPERTENSIONAHA.123.21892