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stearoyl-CoA desaturase; fatty acid desaturase; delta(9)-desaturase (SCD, SCD1)
Enzyme of fatty acid biosynthesis.
Pharmacology:
- modulated by aramchol an investigative agent for NASH
Related
steroyl CoA desaturase gene
Specific
stearoyl-CoA desaturase 5 (HSCD5, acyl-CoA-desaturase 4, stearoyl-CoA 9-desaturase, SCD5, ACOD4, SCD4)
General
dehydrogenase
Properties
MOTIF: active site
Database Correlations
OMIM 604031
UniProt O00767
Pfam PF00487
ENZYME 1.14.99.5
References
- Janowskii et al,
The hypocholesterolemic agent LY295427 reverses suppression of
sterol regulatory element-binding protein processing mediated
by oxysterols.
J Biol Chem 276:45408, 2001
PMID: 11577112
- Wikipedia: Stearoyl-CoA desaturase-1
https://en.wikipedia.org/wiki/Stearoyl-CoA_desaturase-1
Component-of
delta-6 fatty acid desaturase complex