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double-stranded RNA-binding protein Staufen homolog 1 (STAU1, STAU)
Function:
1) binds double-stranded RNA (sequence-independent) & tubulin
2) specific positioning of mRNAs at given sites in the cell by cross-linking cytoskeletal & RNA components, & in stimulating their translation at the site
3) binds with low affinity single-stranded RNA or DNA homopolymers
4) interacts with CASC3 (RNA-dependent)
5) one of the DRDB could be involved in rER binding
6) C-terminal contains the tubulin binding domain
Compartment:
- endoplasmic reticulum
- localizes exclusively with the rough reticulum endoplasmic (rER)
Alternative splicing: named isoforms=2
Expression:
- widely expressed
- expressed in brain, pancreas, heart, skeletal muscles, liver, lung, kidney, placenta
Pathology:
- interacts with influenza virus nonstructural protein NS
General
RNA-binding protein
Properties
SIZE: MW = 63 kD
entity length = 577 aa
COMPARTMENT: endoplasmic reticulum
MOTIF: DRBM 1 {72-162}
DRBM 2 {184-251}
RNA-binding motif
FOR-BINDING-OF: ribonucleic acid
DRBM 3 {286-354}
Database Correlations
OMIM 601716
UniProt O95793
Pfam PF00035
References
UniProt :accession O95793