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statin clinical trials
Clinical trials:
* ASCOT LLA trial, significant benefit for atorvastatin 10 mg QD
* 80 mg atorvastatin prevented more strokes & heart attacks than 10 mg atorvatation (10.3% vs 12.6%) over 5 years, but resulted in more adverse effects (8.3% vs 5.2%)
3809 patients > 65 years of age with coronary artery disease randomly assigned to receive atorvastatin 10 mg or 80 mg QD
primary outcome was 1st major cardiovascular event
Patients were followed for a median of 4.9 years [1]
Specific
ASCOT LLA trial
Jupiter study
General
clinical trial
References
- Wenger NK et al,
Outcomes of using high- or low-dose atorvastatin in patients
65 years of age or older with stable coronary heart disease.
Ann Intern Med 2007, 147:9
PMID: 17606955