StAR-related lipid transfer protein 13; 46H23.2; deleted in liver cancer 2 protein; DLC-2; START domain-containing protein 13; StARD13 (STARD13, DLC2, GT650)

Function: - GTPase-activating protein for RhoA, & perhaps for Cdc42 - may be involved in regulation of cytoskeletal reorganization, cell proliferation & cell motility - acts as s tumor suppressor in hepatocellular carcinoma cells - homodimer - interacts with TAX1BP1 Structure: - contains 1 Rho-GAP domain - contains 1 SAM (sterile alpha motif) domain - contains 1 START domain Compartment: - cytoplasm - peripheral membrane, cytoplasmic side - mitochondrial membrane - lipid droplet Alternative splicing: named isoforms=5 Expression: - ubiquitously expressed Pathology: - underexpressed in hepatocellular carcinoma cells & some breast cancer cell lines

General

rho GTPase-activating protein (rho-GAP) StAR-related lipid transfer protein (START domain-containing protein, StARD)

Properties

SIZE: entity length = 1113 aa MW = 125 kD COMPARTMENT: mitochondria cytoplasm MOTIF: sterile alpha motif NAME: sterile alpha motif SITE: 55-122 Ser phosphorylation site {S133} rho-GAP domain NAME: rho-GAP domain SITE: 663-868 START {899-1107}

Database Correlations

OMIM 609866 UniProt Q9Y3M8 PFAM correlations Entrez Gene 90627 Kegg hsa:90627

References

UniProt :accession Q9Y3M8