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STAM-binding protein (associated molecule with the SH3 domain of STAM, STAMBP, AMSH)
Function:
1) deubiquitinating enzyme, ubiquitin-protein or polyubiquitin hydrolase (putative)
2) functions at the endosome, apposes ubiquitin-dependent sorting of receptors to lysosomes
3) role in signal transduction for cell growth & MYC induction mediated by IL-2 & GM-CSF
4) potentiates BMP (bone morphogenetic protein) signaling by antagonizing the inhibitory action of SMAD6 & SMAD7
5) inhibited by N-ethylmaleimide
6) interacts with STAM1, SMAD6, SMAD7
7) phosphorylated after BMP type 1 receptor activation
ubiquitin C-terminal thioester + H2O ubiquitin + thiol
Structure:
1) binds 1 Zn+2 per subunit
2) belongs to the peptidase M67C family
3) contains 1 MPN domain (JAB/Mov34 domain)
Compartment: nucleus, peripheral membrane, cytoplasm
Expression: ubiquitously expressed
General
metalloprotease
phosphoprotein
Properties
SIZE: MW = 48 kD
entity length = 424 aa
COMPARTMENT: cytoplasm
cell nucleus
MOTIF: Ser phosphorylation site {S2}
Ser phosphorylation site {S48}
glutamate-rich region {104-177}
MOTIF: glutamate residue (SEVERAL)
binding site
SITE: 227-231
FOR-BINDING-OF: signal transducing adapter molecule 1
Ser phosphorylation site {S243}
Ser phosphorylation site {S245}
Ser phosphorylation site {S247}
MPN {252-361}
MOTIF: Zn+2-binding site
SITE: 280-280
Zn+2-binding site
SITE: 335-335
Zn+2-binding site
SITE: 337-337
Zn+2-binding site
SITE: 348-348
Database Correlations
OMIM 606247
UniProt O95630
Pfam PF01398
ENZYME 3.1.2.15
References
UniProt :accession O95630