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STAM3P score; STAM3P algorithm
Indications:
- evaluation of rapidly progressive dementia for treatable causes
Procedure:
- 1 point each for
- seizures
- disease associated tumor
- age < 50 years at onset
- brain MRI suggestive of autoimmune encephalitis
- mania
- movement disorder
- CSF pleocytosis (>= 10 cells/uL)
Interpretation:
- score of 1 at presentation captures 95% of potentially treatment-responsive cases
- all patients with score of >= 3 have potentially treatment-responsive case (sensitivity 26%, specificity 100%)
Notes:
- false-negatives may include
- Wernicke-Korsakoff syndrome
- small-vessel vasculitis
- LGI1 encephalitis
- cerebral amyloid angiopathy with inflammation
General
numerical rating scale (NRS)
References
- Satyadev N, Tipton PW, Martens Y et al.
Improving early recognition of treatment-responsive causes of rapidly progressive
dementia: The STAM3P score.
Ann Neurol 2023 Oct 2; [e-pub].
PMID: 37782554
https://onlinelibrary.wiley.com/doi/10.1002/ana.26812