signal transducing adapter molecule 1 (STAM1)

Function: - role in intracellular signal transduction mediated by cytokines & growth factors - upon IL-2 & GM-CSL stimulation, iit plays a role in signaling leading to DNA synthesis & MYC induction - may also play a role in T-cell development - role in down-regulation of receptor tyrosine kinase via multivesicular body when complexed with HGS (ESCRT-0 complex) - phosphorylated on Tyr-198 - phosphorylated in response to IL2, IL3, IL4, IL7, CSF2/GM-CSF, EGF & PDGFB - phosphorylated by activated PDGFRB - component of the ESCRT-0 complex - probably part of a complex at least composed of HSG, STAM & EPS15 (variant of ESCRT-0 complex) - interacts with STAMBP/AMSH - interacts with PDGFRB Structure: - belongs to the STAM family - contains 1 ITAM domain - contains 1 SH3 domain - contains 1 UIM (ubiquitin-interacting motif) repeat - contains 1 VHS domain Compartment: - cytoplasm (probable) - early endosome membrane - peripheral membrane, cytoplasmic side (probable) Alternative splicing: named isoforms=2 Expression: ubiquitously expressed

Properties

SIZE: entity length = 540 aa MW = 59 kD COMPARTMENT: cytoplasm MOTIF: VHS domain {16-143} Ser phosphorylation site {S156} UIM {171-190} Tyr phosphorylation site {Y198} src homology 3 [SH3] domain SITE: 210-269 ITAM {370-387} MOTIF: Tyr phosphorylation site {Y381} Tyr phosphorylation site {Y384}

Database Correlations

OMIM 601899 UniProt Q92783 PFAM correlations Entrez Gene 8027 Kegg hsa:8027

References

UniProt :accession Q92783