Search
protein SSXT; synovial sarcoma translocated to X chromosome protein; protein SYT (SS18, SSXT, SYT)
Function:
- appears to function synergistically with RBM14 as a transcriptional coactivator
- isoform 1 & isoform 2 function in nuclear receptor coactivation
- isoform 1 & isoform 2 function in general transcriptional coactivation
- interacts with MLLT10
Structure: belongs to the SS18 family
Compartment: nucleus (probable)
Alternative splicing: named isoforms=2
Expression:
- fairly ubiquitously expressed
- expressed in synovial sarcomas & in other human cell lines
- fusion genes SSXT-SSX1 & SSXT-SSX2 are expressed only in synovial sarcomas
Pathology:
- chromosomal translocation t(X;18)(p11.2;q11.2) involving SS18 may be a cause of synovial sarcoma
a) the translocation is specifically found in more than 80% of synovial sarcomas
b) the fusion products SSXT-SSX1 or SSXT-SSX2 are probably responsible for transforming activity
c) heterogeneity in the position of the breakpoint can occur (low frequency)
General
SSX family protein
Properties
SIZE: entity length = 418 aa
MW = 46 kD
COMPARTMENT: cell nucleus
MOTIF: transcriptional activation domain
SITE: 1-186
MOTIF: SH2-binding {50-53}
proline-rich region
SITE: 95-99
MOTIF: proline residue (SEVERAL)
glutamine-rich region {175-418}
MOTIF: glutamine residue (SEVERAL)
2 X 13 AA imperfect tandem repeats {344-369}
consensus repeat {344-356}
consensus repeat {357-369}
breakpoint {366-367}
SH2-binding {374-377}
SH3-binding site
NAME: SH3-binding site
SITE: 392-401
breakpoint {410-411}
SH2-binding {413-416}
Database Correlations
OMIM 600192
UniProt Q15532
Pfam PF05030
Entrez Gene 6760
Kegg hsa:6760
References
- UniProt :accession Q15532
- Atlas of Genetics & Cytogenetics in Oncology & Haematology
http://atlasgeneticsoncology.org/genes/SS18ID84ch18q11.html