protein SSX1; synovial sarcoma, X breakpoint 1; cancer/testis antigen 5.1; CT5.1 (SSX1)

Function: - could act as a modulator of transcription Structure: - belongs to the SSX family - contains 1 KRAB-related domain Expression: - expressed at high level in the testis - expressed at low level in thyroid - not detected in tonsil, colon, lung, spleen, prostate, kidney, striated & smooth muscles - detected in rhabdomyosarcoma & fibrosarcoma cell lines - not detected in mesenchymal & epithelial cell lines Pathology: - chromosomal translocation t(X;18)(p11.2;q11.2) involving SSX1 may be a cause of synovial sarcoma - the translocation is specifically found in more than 80% of synovial sarcomas - fusion products SSXT-SSX1 or SSXT-SSX2 are probably responsible for transforming activity - heterogeneity in the position of the breakpoint can occur (low frequency)

General

phosphoprotein SSX family protein

Properties

SIZE: entity length = 188 aa MW = 22 kD MOTIF: Krueppel-associated box NAME: Krueppel-associated box SITE: 20-83 MOTIF: KRAB A box KRAB B box EFFECTOR-BOUND: Zn+2 breakpoint {62-63} breakpoint {110-111} Ser phosphorylation site {S181}

Database Correlations

OMIM 312820 UniProt Q16384 Pfam PF09514 Entrez Gene 6756 Kegg hsa:6756

References

UniProt :accession Q16384