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protein phosphatase Slingshot homolog 1; SSH-1L; hSSH-1L (SSH1, SSH1L)
Function:
1) regulates actin filament dynamics
2) dephosphorylates & activates cofilin (disassembles actin)
3) LIMK1 phosphorylates & deactivates cofilin
4) interacts with 14-3-3 proteins YWHAB, YWHAG, YWHAQ, & YWHAZ
5) inhibits phosphatase activity
6) inhibitory phosphorylation by PAK4 promotes binding to YWHAZ
7) dephosphorylated & activated by calcineurin A
Structure:
- belongs to the protein-tyrosine phosphatase family
- contains 1 tyrosine-protein phosphatase domain
Compartment:
- cytoplasm
- also recruited to actin rich-membrane protrusions, lamellipodia for cell locomotion
- also localized to the cleavage furrow & the midbody during cytokinesis
Alternative splicing:
- named isoforms=5
- at least one isoform may be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay
General
protein phosphatase Slingshot homolog (ssH)
Properties
SIZE: MW = 116 kD
entity length = 1049 aa
COMPARTMENT: cytoplasm
STATE: active state
MOTIF: TYROSINE-PROTEIN PHOSPHATASE
NAME: TYROSINE-PROTEIN PHOSPHATASE
SITE: 308-448
MOTIF: cysteine residue {C393}
interaction with YWHAG. {897-1049}
MOTIF: Ser phosphorylation site {S978}
Ser phosphorylation site {S1042}
Database Correlations
OMIM 606778
UniProt Q8WYL5
Pfam PF00782
Entrez Gene 54434
Kegg hsa:54434
ENZYME correlations
References
UniProt :accession Q8WYL5