Search
sterol-sensing domain
A multiple transmembrane domain (5 in the case of SCAP) binding site for sterols found in sterol responsive proteins.
General
transmembrane domain
Properties
MOTIF: binding site
FOR-BINDING-OF: sterol
References
- Janowskii et al,
The hypocholesterolemic agent LY295427 reverses suppression of
sterol regulatory element-binding protein processing mediated
by oxysterols.
J Biol Chem 276:45408, 2001
PMID: 11577112
- Osborne T.
CREating a SACP-less liver keeps SREBPs pinned in the ER
membrane and prevents increased lipid synthesis in response
to low cholesterol and high insulin.
Genes & Develop 15:1873, 2001
PMID: 11485982