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serum response factor-binding protein 1 (SRF-dependent transcription regulation-associated protein, p49/STRAP) (SRFBP1)
Function:
- may be involved in regulating transcriptional activation of cardiac genes during the aging process
- may play a role in biosynthesis &/or processing of SLC2A4 in adipose cells
- interacts with SRF
- forms complexes with SRF & SRF cofactors ARID2, MYOCD & NKX2-5
- interacts with the N-terminus of SLC2A4 (putative)
Compartment: cytoplasm, perinuclear region
Expression:
- abundantly expressed in heart & skeletal muscle, & at much lower levels in brain & lung
- up-regulated in adult heart (at protein level)
General
phosphoprotein
Properties
SIZE: entity length = 429 aa
MW = 49 kD
COMPARTMENT: cytoplasm
cell nucleus
MOTIF: coiled coil {42-67}
coiled coil {108-146}
Ser phosphorylation site {S203}
Tyr phosphorylation site {Y270}
Ser phosphorylation site {S273}
Ser phosphorylation site {S274}
Ser phosphorylation site {S276}
Ser phosphorylation site {S281}
Database Correlations
UniProt Q8NEF9
Pfam PF09073
Kegg hsa:1534
References
UniProt :accession Q8NEF9