3-oxo-5-alpha-steroid 4-dehydrogenase 3; steroid 5-alpha reductase 3; testosterone 5-alpha reductase 3; SR type 3; steroid 5-alpha-reductase 2-like (SRD5A3, SRD5A2L)

Function: - converts testosterone into 5-alpha-dihydrotestosterone 3-oxo-5-alpha-steroid + acceptor 3-oxo-delta(4)-steroid + reduced acceptor Structure: belongs to the steroid 5-alpha reductase family Compartment: microsome membrane Expression: almost no or little expression in normal adult organs Pathology: - overexpressed in hormone-refractory prostate cancers

General

3-oxo-5-alpha-steroid 4 dehydrogenase; steroid 5-alpha reductase; testosterone 5-alpha reductase membrane protein

Properties

SIZE: entity length = 318 aa MW = 37 kD COMPARTMENT: cellular membrane MOTIF: transmembrane domain {12-34} transmembrane domain {81-101} transmembrane domain {118-138} transmembrane domain {158-178} transmembrane domain {195-215} transmembrane domain {261-281}

Database Correlations

UniProt Q9H8P0 Pfam PF02544 Kegg hsa:7964 ENZYME 1.3.99.5

References

UniProt :accession Q9H8P0