Spermatogenic leucine zipper protein 1 (testis-specific protein 1, testis-specific protein NYD-TSP1, SPZ1, TSP1)

Function: - transcription factor that binds to the DNA sequence 5'-CANNTG-3'(E box) & the G-box motif - role in regulation of cell proliferation & differentiation during spermatogenesis - interacts with PPP1CC isoform gamma-2 - phosphorylated by ERK1 & ERK2 Structure: - contains 1 basic helix-loop-helix (bHLH) domain Compartment: cytoplasm, nucleus Alternative splicing: named isoforms=2 Expression: - specifically & strongly expressed in testis Pathology: - expressed in several tumor cell lines

General

basic helix loop helix (bHLH) family transcription factor phosphoprotein testis-specific protein

Properties

SIZE: MW = 49 kD entity length = 430 aa COMPARTMENT: cytoplasm cell nucleus MOTIF: coiled coil {62-102} helix-loop-helix NAME: helix-loop-helix SITE: 166-177 FOR-BINDING-VIA: helix-loop-helix DNA-binding motif SITE: 178-244 coiled coil {214-269} leucine zipper SITE: 303-324 FOR-BINDING-VIA: leucine zipper coiled coil {316-351}

References

UniProt :accession Q9BXG8