Search
protein Plunc; palate lung & nasal epithelium clone protein; lung-specific protein X; nasopharyngeal carcinoma-related protein; tracheal epithelium-enriched protein; secretory protein in upper respiratory tracts; von Ebner protein Hl (PLUNC, BPIFA1, LUNX, NASG, SPURT, UNQ787/PRO1606)
Function:
1) role in innate immune responses of the upper airways
- role in airway inflammatory response after exposure to irritants (putative)
2) binds lipopolysaccharides
Structure:
- belongs to the BPI/LBP/Plunc superfamily, Plunc family
- N-glycosylated (putative)
Compartment:
- secreted
- found in nasal mucus
- pical side of airway epithelial cells
Expression:
- lung, upper airways & nasopharyngeal regions, including trachea & nasal epithelium
- specifically expressed in secretory ducts & submucosal glands of tracheobronchial tissues
- highest expression in trachea & progressive decrease from proximal (bronchial) to distal (bronchiolar) airways
- induced by all-trans retinoic acid (ATRA)
Pathology:
- expressed in lung cancers & some other types of cancer
- associated with tumor progression (putative)
General
secreted protein
Properties
SIZE: MW = 27 kD
entity length = 256 aa
COMPARTMENT: extracellular compartment
MOTIF: signal sequence {1-19}
Database Correlations
OMIM 607412
UniProt Q9NP55
Pfam PF01273
References
UniProt :accession Q9NP55