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small proline-rich protein 2A; SPR-2A; 2-1 (SPRR2A)
Function:
- cross-linked envelope protein of keratinocytes
- keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase; this results in the formation of an insoluble envelope beneath the plasma membrane
Structure: belongs to the cornifin (SPRR) family
Compartment: cytoplasm
Expression:
- expressed during squamous differentiation of epidermal keratinocytes
General
small proline-rich protein 2
Properties
SIZE: entity length = 72 aa
MW = 8 kD
COMPARTMENT: cytoplasm
MOTIF: domain {21-47}
MOTIF: consensus repeat {21-29}
consensus repeat {30-38}
consensus repeat {39-47}
proline-rich region
MOTIF: proline residue (SEVERAL)
Database Correlations
OMIM 182267
UniProt P35326
Entrez Gene 6700
Kegg hsa:6700
References
UniProt :accession P35326