Search
signal peptide peptidase-like 2B; SPP-like 2B; SPPL2b; intramembrane protease 4; IMP-4; presenilin-like protein 1 (SPPL2B, IMP4, KIAA1532, PSL1)
Function:
- intramembrane protease
- role in ITM2B processing
- interacts with ITM2B
Structure:
- belongs to the peptidase A22B family
- contains 1 PA (protease associated) domain
Compartment:
- Golgi membrane; multi-pass membrane protein
Alternative splicing: named isoforms=4
General
presenilin-like protein
transmembrane 7 protein
Properties
SIZE: entity length = 592 aa
MW = 65 kD
COMPARTMENT: golgi
MOTIF: cytoplasmic domain {1-174}
MOTIF: PA {55-155}
transmembrane domain {175-195}
exoplasmic loop {196-236}
transmembrane domain {237-257}
cytoplasmic loop {258-293}
transmembrane domain {294-314}
exoplasmic loop {315-319}
transmembrane domain {320-340}
cytoplasmic loop {341-348}
transmembrane domain {349-369}
MOTIF: aspartate residue {D359}
exoplasmic loop {370-412}
transmembrane domain {413-433}
MOTIF: aspartate residue {D421}
cytoplasmic loop {434-445}
transmembrane domain {446-466}
proline-rich region
SITE: 509-551
MOTIF: proline residue (SEVERAL)
Database Correlations
OMIM 608239
UniProt Q8TCT7
PFAM correlations
Entrez Gene 56928
Kegg hsa:56928
References
UniProt :accession Q8TCT7