Search
signal peptide peptidase-like 2A; SPP-like 2A; SPPL2a; intramembrane protease 3; IMP-3; presenilin-like protein 2 (SPPL2A, IMP3, PSL2, PSEC0147)
Function:
- intramembrane protease
- ITM2B processing
- interacts with ITM2B
Structure:
- belongs to the peptidase A22B family
- contains 1 PA (protease associated) domain
Compartment: membrane
General
presenilin-like protein
transmembrane 9 protein
Properties
SIZE: entity length = 520 aa
MW = 58 kD
COMPARTMENT: cellular membrane
MOTIF: cytoplasmic domain {1-172}
MOTIF: PA {55-152}
transmembrane domain {173-193}
exoplasmic loop {194-220}
transmembrane domain {221-241}
cytoplasmic loop {242-247}
transmembrane domain {248-268}
exoplasmic loop {269-285}
transmembrane domain {286-306}
cytoplasmic loop {307-311}
transmembrane domain {312-332}
exoplasmic loop {333-340}
transmembrane domain {341-361}
MOTIF: aspartate residue {D351}
cytoplasmic loop {362-399}
transmembrane domain {400-420}
MOTIF: aspartate residue {D412}
exoplasmic loop {421-437}
transmembrane domain {438-458}
cytoplasmic loop {459-460}
transmembrane domain {461-481}
Database Correlations
OMIM 608238
UniProt Q8TCT8
PFAM correlations
Entrez Gene 84888
Kegg hsa:84888
References
UniProt :accession Q8TCT8