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speckle-type POZ protein (SPOP)
Function:
1) inhibits IPF1/PDX1 transactivation of promoters, including insulin gene promoter
2) recruits transcription repressor complex (putative)
3) ubiquitination of both PCGF4 & H2AFY, in association with CUL3
4) ubiquitin conjugation, 3rd step
5) component of complex consisting of PCGF4, CUL3 & SPOP
6) component of complex consisting of H2AFY, CUL3 & SPOP
7) interacts with H2AFY, IPF1/PDX1 & PCGF4
- MATH domain interacts with H2AFY & PCGF4
Structure:
1) belongs to the Tdpoz family
2) contains 1 BTB domain (POZ domain)
3) contains 1 MATH domain
Compartment: nucleus
Expression: widely expressed
Pathology:
- antigen recognized by serum from scleroderma patient
General
other protein
Properties
SIZE: MW = 42 kD
entity length = 374 aa
COMPARTMENT: cell nucleus
MOTIF: MATH {31-161}
nuclear localization {71-191}
BTB domain {173-297}
MOTIF: Zinc finger
NAME: Zinc finger
EFFECTOR-BOUND: Zn+2
Database Correlations
OMIM 602650
UniProt O43791
PFAM correlations
References
UniProt :accession O43791